Modification of Biocorrosion and Cellular Response of Magnesium Alloy WE43 by Multiaxial Deformation

The study shows that multiaxial deformation (MAD) treatment leads to grain refinement in magnesium alloy WE43. Compared the initial state, MAD-processed exhibited smoother biocorrosion dynamics a fetal bovine serum and complete cell growth medium. Examination by microCT demonstrated retardation of decline volume Hounsfield unit values. An attendant reduction rate accumulation biodegradation products immersion medium, less pronounced alkalization, inhibited sedimentation on surface were observed after MAD. These effects accompanied with an increase osteogenic mesenchymal stromal viability medium containing their extracts. It is expected more orderly WE43 MAD stimulation colonization will effectively promote stable osteosynthesis, making repeat implant extraction surgeries unnecessary.